Amide naphthotubes:Biomimetic macrocycles for selective molecular recognition
作者机构：School of Pharmaceutical SciencePostdoctoral Research Station of Basic MedicineHengyang Medical SchoolUniversity of South ChinaHengyang 421001China
出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)
年 卷 期：2024年第35卷第4期
页 面：124-131页
核心收录：
学科分类：07[理学] 070205[理学-凝聚态物理] 070304[理学-物理化学(含∶化学物理)] 0703[理学-化学] 0702[理学-物理学]
基 金：the National Natural Science Foundation of China(Nos.22174059 and 22201128) Hunan Provincial Natural Science Foundation of China(Nos.2022JJ40363 and 2022JJ40365) the Young Science and Technology Innovation Program of Hunan Province(No.2022RC1230) China Postdoctoral Science Foundation(No.2022M721542)for financial support。
主 题：Molecular recognition Supramolecular chemistry Amide naphthotube Endo-functionalized cavity Biomimetic macrocycle
摘 要：Selective molecular recognition in water is routine for bioreceptors,but remains challenging for synthetic hosts.This is principally because noncovalent interactions are usually less efficient in aqueous environments.By mimicking the cavity feature of bioreceptors,Prof.Wei Jiang proposed and clarified the concept of“endo-functionalized cavity.Through situating polar binding sites into a deep hydrophobic cavity,we designed and synthesized several macrocyclic hosts,among which amide naphthotubes are the most representative.The hosts can selectively recognize various polar molecules including organic micropollutants,drug molecules,and chiral molecules in water by employing the hydrophobic effect and shielded hydrogen bonding.In addition,these biomimetic hosts have been applied in spectroscopic analysis,adsorptive separation and self-assembly.In this review,we provide an overview of recent advances on amide naphthotubes with special emphasis on the efforts of Jiang s group.We are convinced that these biomimetic macrocycles will make further contributions to supramolecular chemistry and beyond.
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