Probing the dynamic thermodynamic resolution and biological activity of Cu(Ⅱ) and Pd(Ⅱ) complexes with Schiff base ligand derived from proline

作     者：Tao Yu Vadim A.Soloshonok Zhekai Xiao Hong Liu Jiang Wang Tao Yu;Vadim A.Soloshonok;Zhekai Xiao;Hong Liu;Jiang Wang

作者机构：State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China School of PharmacyUniversity of Chinese Academy of SciencesBeijing 100049China Department of Organic Chemistry ⅠFaculty of ChemistryUniversity of the Basque Country UPV/EHUSan Sebastian 20018Spain IKERBASQUEBasque Foundation for ScienceBilbao 48013Spain School of Pharmaceutical Science and TechnologyHangzhou Institute for Advanced StudyUCASHangzhou 310024China Lingang LaboratoryShanghai 200031China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2024年第35卷第4期

页      面：99-105页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 07[理学] 070304[理学-物理化学(含∶化学物理)] 0703[理学-化学] 10[医学] 

基　　金：the National Key R&D Program of China(No.2022YFA1302900) the National Natural Science Foundation of China (Nos.82130105, 92253305, 82121005, and 22177124) supported by the Lingang Laboratory (Nos.LG-GG-202204–02 and LG202103–04–01)。 

主　　题：Schiff bases Biological activity Tailor-made amino acids Asymmetric synthesis Chiral tridentate ligands Square-planar Cu(Ⅱ)-complexes Square-planar Pd(Ⅱ)-complexes 

摘      要：Schiff base metal complexes are of great importance in pharmaceutical science owing to their unique chemical properties, which enable them to exhibit diverse biological activities such as anti-bacterial,anti-oxidant, anti-inflammatory, and anti-tumor properties. Furthermore, Schiff base metal complexes can serve as reagents and catalysts in chemical reactions. This review aims to provide an overview of our recently published studies on Cu(Ⅱ) and Pd(Ⅱ) complexes derived from proline Schiff base ligands. We also discuss the potential applications of these metal complexes in the fields of antibacterial and chiral resolution.