Sympathetic nerve signals: orchestrators of mammary development and stem cell vitality
作者机构：Department of Pulmonary OncologyHubei Province Cancer Clinical Study CenterHubei Key Laboratory of Tumor Biological BehaviorsZhongnan Hospital of Wuhan UniversityFrontier Science Center for Immunology and MetabolismMedical Research InstituteWuhan UniversityWuhan 430071China Key Laboratory of Systems Health Science of Zhejiang ProvinceSchool of Life ScienceHangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China
出 版 物：《Journal of Molecular Cell Biology》 (分子细胞生物学报（英文版）)
年 卷 期：2024年第16卷第5期
页 面：29-45页
核心收录：
学科分类：0809[工学-电子科学与技术（可授工学、理学学位）] 08[工学]
基 金：This work was supported by grants from the Ministry of Science and Technology of China(National Program on Key Basic Research Project:2019YFA0802804 to L.Y.) the National Natural Science Foundation of China(31871492 and 32270837 to C.C.) Hubei Provincial Natural Science Foundation(2023AFB784 to Y.X.) the Fundamental Research Funds for the Central Universities(2042022kf1146 to Y.X.and 2042022dx0003)
主 题：mammary development mammary stem cells sympathetic nerve mammary microenvironment
摘 要：The mammary gland is a dynamic organ that undergoes significant changes at multiple stages of postnatal *** the roles of systemic hormones and microenvironmental cues in mammary homeostasis have been extensively studied,the influence of neural signals,particularly those from the sympathetic nervous system,remains poorly ***,using a mouse mammary gland model,we delved into the regulatory role of sympathetic nervous signaling in the context of mammary stem cells and mammary *** findings revealed that depletion of sympathetic nerve signals results in defective mammary development during puberty,adulthood,and pregnancy,accompanied by a reduction in mammary stem cell *** in vitro three-dimensional culture and in vivo transplantation analyses,we demonstrated that the absence of sympathetic nerve signals hinders mammary stem cell self-renewal and regeneration,while activation of sympathetic nervous signaling promotes these ***,sympathetic nerve signals orchestrate mammary stem cell activity and mammary development through the extracellular signal-regulated kinase signaling ***,our study unveils the crucial roles of sympathetic nerve signals in sustaining mammary development and regulating mammary stem cell activity,offering a novel perspective on the involvement of the nervous system in modulating adult stem cell function and organ development.
维普期刊数据库