Interplay between mesenchymal stem cells and macrophages:Promoting bone tissue repair

作     者：Fei-Fan Zhang Yang Hao Kuai-Xiang Zhang Jiang-Jia Yang Zhi-Qiang Zhao Hong-Jian Liu Ji-Tian Li 

作者机构：Molecular Biology LabHenan Luoyang Orthopedic Hospital(Henan Provincial Orthopedic Hospital)Zhengzhou 450000Henan ProvinceChina Graduate SchoolHunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Graduate SchoolHenan University of Chinese MedicineZhengzhou 450046Henan ProvinceChina Department of OrthopaedicsThe First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina 

出 版 物：《World Journal of Stem Cells》 (世界干细胞杂志（英文版）（电子版）)

年 卷 期：2024年第16卷第4期

页      面：375-388页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 0710[理学-生物学] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 

基　　金：Supported by the National Key Research and Development Program of China,No.2023YFC2508806 Key Research and Development Project in Henan Province,No.231111310500 Young Elite Scientists Sponsorship Program by CAST,No.2021-QNRC2-A06 Scientific Research Project of Henan Zhongyuan Medical Science and Technology Innovation and Development Foundation,No.ZYYC2023ZD Youth Science Award Project of the Provincial-Level Joint Fund for Science and Technology Research and Development Project in Henan Province,No.225200810084 Special Project on Training Top Talents in Traditional Chinese Medicine in Henan Province,No.2022ZYBJ24 2023 Hunan University of Chinese Medicine Postgraduate Innovation Project,No.2023CX64。 

主　　题：Bone tissue damage Inflammation Macrophages Mesenchymal stem cells Tissue regeneration 

摘      要：The repair of bone tissue damage is a complex process that is well-orchestrated in time and space,a focus and difficulty in orthopedic treatment.In recent years,the success of mesenchymal stem cells(MSCs)-mediated bone repair in clinical trials of large-area bone defects and bone necrosis has made it a candidate in bone tissue repair engineering and regenerative medicine.MSCs are closely related to macrophages.On one hand,MSCs regulate the immune regulatory function by influencing macrophages proliferation,infiltration,and phenotype polarization,while also affecting the osteoclasts differentiation of macrophages.On the other hand,macrophages activate MSCs and mediate the multilineage differentiation of MSCs by regulating the immune microenvironment.The cross-talk between MSCs and macrophages plays a crucial role in regulating the immune system and in promoting tissue regeneration.Making full use of the relationship between MSCs and macrophages will enhance the efficacy of MSCs therapy in bone tissue repair,and will also provide a reference for further application of MSCs in other diseases.