A flexible,thin-film microchannel electrode array device for selective subdiaphragmatic vagus nerve recording

作     者：Jongcheon Lim Peter A.Zoss Terry L.Powley Hyowon Lee Matthew P.Ward 

作者机构：Weldon School of Biomedical EngineeringPurdue UniversityWest LafayetteINUSA Birck Nanotechnology CenterPurdue UniversityWest LafayetteINUSA Center for Implantable DevicesPurdue UniversityWest LafayetteINUSA Department of Psychological SciencesPurdue UniversityWest LafayetteINUSA Purdue Institute of Integrative NeurosciencePurdue UniversityWest LafayetteINUSA Indiana University School of MedicineIndianapolisINUSA 

出 版 物：《Microsystems & Nanoengineering》 (微系统与纳米工程（英文）)

年 卷 期：2024年第10卷第1期

页      面：115-128页

核心收录：

学科分类：08[工学] 0804[工学-仪器科学与技术] 0805[工学-材料科学与工程（可授工学、理学学位）] 

基　　金：supported by NIH SPARC Program(OT2 OD028183) supported in part by the National Science Foundation(United States)under the grant ECCS-1944480。 

主　　题：electrode recording film 

摘      要：The vagus nerve(VN)plays an important role in regulating physiological conditions in the gastrointestinal(GI)tract by communicating via the parasympathetic pathway to the enteric nervous system(ENS).However,the lack of knowledge in the neurophysiology of the VN and GI tract limits the development of advanced treatments for autonomic dysfunctions related to the VN.To better understand the complicated underlying mechanisms of the VN-GI tract neurophysiology,it is necessary to use an advanced device enabled by microfabrication technologies.Among several candidates including intraneural probe array and extraneural cuff electrodes,microchannel electrode array devices can be used to interface with smaller numbers of nerve fibers by securing them in the separate channel structures.Previous microchannel electrode array devices to interface teased nerve structures are relatively bulky with thickness around 200µm.The thick design can potentially harm the delicate tissue structures,including the nerve itself.In this paper,we present a flexible thin film based microchannel electrode array device(thickness:11.5µm)that can interface with one of the subdiaphragmatic nerve branches of the VN in a rat.We demonstrated recording evoked compound action potentials(ECAP)from a transected nerve ending that has multiple nerve fibers.Moreover,our analysis confirmed that the signals are from C-fibers that are critical in regulating autonomic neurophysiology in the GI tract.