Quantitative hepatitis B core antibody and quantitative hepatitis B surface antigen:Novel viral biomarkers for chronic hepatitis B management
作者机构：Department of Clinical Tropical MedicineMahidol UniversityRachatawee 10400BangkokThailand Department of MedicineSrinakharinwirot UniversityWattana 10110BangkokThailand
出 版 物：《World Journal of Hepatology》 (世界肝病学杂志（英文版）（电子版）)
年 卷 期：2024年第16卷第4期
页 面：550-565页
学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100401[医学-流行病与卫生统计学] 10[医学]
主 题：Quantitative hepatitis B core antibody Quantitative hepatitis B surface antigen Chronic hepatitis B management Novels viral biomarkers
摘 要：The management of hepatitis B virus(HBV)infection now involves regular and appropriate monitoring of viral activity,disease progression,and treatment *** HBV infection biomarkers are limited in their ability to predict clinical outcomes or therapeutic *** of HBV core antibodies(qAnti-HBc)is a novel non-invasive biomarker that may help with a variety of diagnostic *** was shown to correlate strongly with infection stages,hepatic inflammation and fibrosis,chronic infection exacerbations,and the presence of occult ***,qAnti-HBc levels were shown to be predictive of spontaneous or treatment-induced HBeAg and HBsAg seroclearance,relapse after medication termination,re-infection following liver transplantation,and viral reactivation in the presence of ***-HBc,on the other hand,cannot be relied on as a single diagnostic test to address all problems,and its diagnostic and prognostic potential may be greatly increased when paired with *** qAnti-HBc diagnostic kits are currently not widely *** many methodologies are only semi-quantitative,comparing data from various studies and defining universal cut-off values remains *** review focuses on the clinical utility of qAnti-HBc and qHBsAg in chronic hepatitis B management.
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