Single-cell analysis revealing the metabolic landscape of prostate cancer
作者机构：Department of Urologic OncologyThe First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230031China Department of UrologyThe First Affiliated Hospital of Anhui Medical UniversityHefei 230001China Institute of UrologyAnhui Medical UniversityHefei 230001China Anhui Province Key Laboratory of Genitourinary DiseasesAnhui Medical UniversityHefei 230001China Department of GeneticsUniversity of North CarolinaChapel HillNC 27599USA Department of GeriatricsThe First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Department of UrologyThe First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China
出 版 物：《Asian Journal of Andrology》 (亚洲男性学杂志（英文版）)
年 卷 期：2024年第26卷第5期
页 面：451-463页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：supported by the National Natural Science Foundation of China(No.81902611,82272886,and 82200484) USTC Research Funds of the Double First-Class Initiative(YD9110002041) the Natural Science Foundation of Anhui Education Department(No.2022AH030118)
主 题：cancer heterogeneity cancer metabolism glutamine prostate cancer single-cell sequencing
摘 要：Tumor metabolic reprogramming is a hallmark of cancer development,and targeting metabolic vulnerabilities has been proven to be an effective approach for castration-resistant prostate cancer(CRPC)***,treatment failure inevitably occurs,largely due to cellular heterogeneity,which cannot be deciphered by traditional bulk sequencing *** employing computational pipelines for single-cell RNA sequencing,we demonstrated that epithelial cells within the prostate are more metabolically active and plastic than stromal ***,we identified that neuroendocrine(NE)cells tend to have high metabolic rates,which might explain the high demand for nutrients and energy exhibited by neuroendocrine prostate cancer(NEPC),one of the most lethal variants of prostate cancer(PCa).Additionally,we demonstrated through computational and experimental approaches that variation in mitochondrial activity is the greatest contributor to metabolic heterogeneity among both tumor cells and nontumor *** results establish a detailed metabolic landscape of PCa,highlight a potential mechanism of disease progression,and emphasize the importance of future studies on tumor heterogeneity and the tumor microenvironment from a metabolic perspective.
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