具有骨样微环境的压电催化可控矿化支架实现内源性骨再生

作     者：崔希 胥玲玲 单义珠 李佳宣 吉健颖 汪恩贵 张葆堃 文晓舟 白源 罗聃 陈春英 李舟 Xi Cui;Lingling Xu;Yizhu Shan;Jiaxuan Li;Jianying Ji;Engui Wang;Baokun Zhang;Xiaozhou Wen;Yuan Bai;Dan Luo;Chunying Chen;Zhou Li

作者机构：Beijing Key Laboratory of Micro-nano Energy and SensorBeijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijing 101400China School of Nanoscience and EngineeringUniversity of Chinese Academy of SciencesBeijing 100049China New Cornerstone Science LaboratoryCAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China 

出 版 物：《Science Bulletin》 (科学通报（英文版）)

年 卷 期：2024年第69卷第12期

页      面：1895-1908页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

基　　金：supported by Beijing Natural Science Foundation(L212010) the National Natural Science Foundation of China(T2125003,52372174) the New Cornerstone Science Foundation,Major Instrument Project of the National Natural Science Foundation of China(22027810) the National Key Research and Development Program of China(2022YFB3804703,2022YFE0111700,2021YFA1200900,2021YFB3201204,2022YFB3205602) 

主　　题：Piezoelectric catalysis Controllable mineralization Biomimetic Bone repair Biodegradable 

摘      要：Orderly hierarchical structure with balanced mechanical,chemical,and electrical properties is the basis of the natural bone *** by nature,we developed a piezocatalytically-induced controlled mineralization strategy using piezoelectric polymer poly-L-lactic acid(PLLA)fibers with ordered micro-nano structures to prepare biomimetic tissue engineering scaffolds with a bone-like microenvironment(pcm-PLLA),in which PLLA-mediated piezoelectric catalysis promoted the in-situ polymerization of dopamine and subsequently regulated the controllable growth of hydroxyapatite crystals on the fiber *** fibers,as analogs of mineralized collagen fibers,were arranged in an oriented manner,and ultimately formed a bone-like interconnected pore structure;in addition,they also provided bone-like piezoelectric *** uniformly sized HA nanocrystals formed by controlled mineralization provided a bone-like mechanical strength and chemical *** pcm-PLLA scaffold could rapidly recruit endogenous stem cells,and promote their osteogenic differentiation by activating cell membrane calcium channels and PI3K signaling pathways through ultrasound-responsive piezoelectric *** addition,the scaffold also provided a suitable microenvironment to promote macrophage M2 polarization and angiogenesis,thereby enhancing bone regeneration in skull defects of *** proposed piezocatalytically-induced controllable mineralization strategy provides a new idea for the development of tissue engineering scaffolds that can be implemented for multimodal physical stimulation therapy.