Mitochondrial aberrations in systemic lupus erythematosus pathogenesis:Insights and therapeutic implications

作     者：Haoguang Li Lu Zhou Wei Zhou Xiuling Zhang Jingjing Shang Xueqin Feng Le Yu Jie Fan Jie Ren Rongwei Zhang Xinwang Duan 

作者机构：Department of Rheumatology and ImmunologyThe Second Affiliated Hospital of Nanchang UniversityNanchangChina 

出 版 物：《Rheumatology & Autoimmunity》 (风湿病与自身免疫（英文）)

年 卷 期：2024年第4卷第2期

页      面：69-80页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Key Research and Development Program of Jiangxi Municipal Science and Technology Department,Grant/Award Number:20192BBGL70024 Science and Technology Program of Department of Health of Jiangxi Province,Grant/Award Number:20204254 National Key Research and Development Program of China,Grant/Award Number:2021YFC2501304 

主　　题：mitochondrial dysfunctions mitophagy oxidative stress systemic lupus erythematosus therapeutic potential 

摘      要：Systemic lupus erythematosus(SLE),a chronic autoimmune disease,is marked by impaired immune tolerance and heightened activity in both innate and adaptive immune *** of SLE include elevated type I interferons and autoantibody production,though the exact causes of SLE remain elusive despite advances in research *** to SLE research is understanding its pathogenesis and developing effective diagnostic and therapeutic *** studies have highlighted a significant link between mitochondrial abnormalities and SLE s development and *** dysfunction plays a key role in SLE pathogenesis through various mechanisms such as mitochondrial DNA mutations,oxidative stress,immune metabolic reprogramming,and cellular *** factors collectively contribute to the loss of self-tolerance,increased autoantibody production,and impaired clearance of immune complexes,leading to their *** triggers sustained inflammatory responses and damages multiple *** review focuses on the diagnostic and therapeutic approaches related to mitochondrial abnormalities in *** mitochondrial pathways presents a promising strategy for treating SLE,potentially improving prognosis and quality of life for those *** research should further investigate the role of mitochondria in the onset and progression of SLE,providing new avenues for understanding and managing this complex disease.