Phosphine-Catalyzed [4+3] Annulation Reaction of Indole Derivatives with MBH Carbonates:A Facile Access to Indole-1,2-fused 1,4-Diazepinones and Azepines
[4+3] Annulation Reaction of Indole Derivatives with MBH Carbonates: A Facile Access to Indole-1,2-fused 1,4-Diazepinones and Azepines作者机构：Faculty of Chemistry and Chemical EngineeringYancheng Institute of TechnologyYanchengJiangsu224051 China
出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)
年 卷 期：2024年第42卷第3期
页 面：271-275页
核心收录：
学科分类：07[理学] 070303[理学-有机化学] 0703[理学-化学]
基 金：the financial support from the funding for school-level research projects of Yancheng Institute of Technology(No.XJR2022019 XJ201719).
主 题：Phosphine catalysis [4+3]Annulation Indole derivatives Nitrogen heterocycles Organocatalysis
摘 要：A phosphine-catalyzed [4+3] annulation between dinucleophilic indole derivatives and Morita−Baylis−Hillman (MBH) carbonates was discovered by using the N1 and N4′/C4′ nucleophilicities of the indole precursors,in which indoles act as four atom synthons. This protocol provides an efficient and facile access to indole-1,2-fused 1,4-diazepinones and azepines in good to high yields in one step,which illustrates potential synthetic utilities in drug discovery.
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