Acute Toxicity of Jinchuan Formula Plum Wine Extract and Its Protective Effect on Mice with Liver Injury

作     者：Hairong ZHONG Yun TENG Limin LI Yuan LIU 

作者机构：College of PharmacySichuan College of Traditional Chinese MedicineMianyang 621000China Chengdu Brilliant Pharmaceuticals Co.Ltd.Chengdu 610095China Sichuan Academy of Chinese Medicine SciencesChengdu 610041China Ethnic Medicine InstituteSouthwest Minzu UniversityChengdu 610041China 

出 版 物：《Medicinal Plant》 (药用植物：英文版)

年 卷 期：2024年第15卷第2期

页      面：30-32,37页

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

主　　题：Jinchuan formula plum wine extract Acute toxicity test ConA-induced liver injury Liver protective effect 

摘      要：[Objectives]To investigate the acute toxicity and hepatoprotective effect of Jinchuan formula plum wine extract on mice,determine its safety range,and evaluate its hepatoprotective effect.[Methods]The median lethal dose(LD_(50))was determined by acute toxicity test with the toxic reaction and mortality of mice as *** Kunming mice were randomly divided into 6 groups:normal control group,model group(ConA-induced liver injury model),Jinchuan formula plum wine high,medium and low dose groups(1.0,0.5,0.25 g/kg)and silybin group(0.1 g/kg).The levels of ALT,AST,LDH in serum and TG,VLDL in liver were *** HE staining,the pathological changes of liver tissue in mice were observed,and the liver protective effect of Jinchuan formula plum wine extract was analyzed and evaluated.[Results]LD_(50)was 11.18 g/kg,and the 95%confidence limit of LD_(50)was 10.31-12.05 g/*** high-dose group of Jinchuan formula plum wine extract could significantly reduce the serum ALT and AST activities of ConA-induced liver injury mice(P0.05).[Conclusions]Jinchuan formula plum wine extract is relatively safe,and also has a protective effect on liver injury.