Potential risk genes for primary Sjogren's syndrome from a meta-analysis by linear regression and random forest classification

作     者：Tomas Cerdo Teresa Torres Moral Tomás Cerdó;Teresa Torres Moral

作者机构：Maimonides Biomedical Research Institute of Cordoba(IMIBIC)Reina Sofia University HospitalUniversity of CordobaCordoba 14004Spain Centre for Rheumatology ResearchDivision of MedicineUniversity College LondonLondon W1T 4JFUK Faculty of Computer SciencesMultimedia and TelecommunicationUniversitat Oberta de CatalunyaBarcelona 08018Spain Dermatology DepartmentMelanoma UnitAugust Pi i Sunyer Biomedical Research Institute(IDIBAPS)and Hospital ClinicBarcelona 08036Spain Center for Networked Biomedical Research on Rare Diseases(CIBERER)Carlos II Health InstituteMadrid 28029Spain 

出 版 物：《Genes & Diseases》 (基因与疾病（英文）)

年 卷 期：2024年第11卷第3期

页      面：128-131页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 10[医学] 

基　　金：Tomas Cerdo was supported by'Sara Borrell'programmes(CD21/00187)from the Institute of Health Carlos III(ICIII). 

主　　题：Sjogren lymphocytic salivary 

摘      要：Primary Sjogren s syndrome(psS)is one of the most widespread autoimmune diseases with unknown origin,characterized by a lymphocytic infiltrate of the exocrine glands and the production of anti-SSA/Ro and anti-SSB/La antibodies that cause dysfunction and destruction mainly of salivary and lachrymal glands,leading to dry eyes and dry mouth.In the absence of a standardized evidence-based screening tool to decide which patients with dry eye must be referred for study of this pathology.