Development and validation of an immunogenic cell death-related prognostic model, and landscape of the tumor immune microenvironment in glioblastoma

作     者：Sha Yang Mei Deng Yunbiao Xiong Bing Xiong Junwu Fu Jia Wang Jiqin Zhang Guoqiang Han Jian Liu Ying Tan Sha Yang;Mei Deng;Yunbiao Xiong;Bing Xiong;Junwu Fu;Jia Wang;Jiqin Zhang;Guoqiang Han;Jian Liu;Ying Tan

作者机构：Guizhou University Medical CollegeGuiyangGuizhou 550025China Department of NeurosurgeryGuizhou Provincial People's HospitalGuiyangGuizhou 550002China Department of AnesthesiologyGuizhou Provincial People's HospitalGuiyangGuizhou 550002China Department of NeurosurgeryChongqing Emergency Medical CenterChongqing400000China 

出 版 物：《Genes & Diseases》 (基因与疾病（英文）)

年 卷 期：2024年第11卷第3期

页      面：72-74页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：immune Cancer prognosis 

摘      要：The important role of immunogenic cell death(ICD)in many tumors is increasingly being discovered.However,its mechanisms and potential as a biomarker and therapeutic target in glioblastoma(GBM)have not been well studied.We obtained GBM samples from the Cancer Genome Atlas(TCGA)and Gene Expression Omnibus(GEO)databases,as well as the immunotherapy cohort from the IMvigor210 study.We used unsupervised clustering to obtain two ICDrelated clusters,corresponding to the ICD-low and ICD-high subtypes respectively,and the tumor immune microenvironment and prognosis of the two subtypes were significantly different.