Mechanisms and biotechnological applications of transcription factors

作     者：Hehe He Mingfei Yang Siyu Li Gaoyang Zhang Zhongyang Ding Liang Zhang Guiyang Shi Youran Li 

作者机构：Key Laboratory of Industrial BiotechnologyMinistry of EducationSchool of BiotechnologyJiangnan UniversityWuxiJiangsu Province 214122PR China National Engineering Research Center of Cereal Fermentation and Food BiomanufacturingJiangnan University1800 Lihu AvenueWuxiJiangsu Province 214122PR China Jiangsu Provisional Research Center for Bioactive Product Processing TechnologyJiangnan University1800 Lihu AvenueWuxiJiangsu Province 214122PR China 

出 版 物：《Synthetic and Systems Biotechnology》 (合成和系统生物技术（英文）)

年 卷 期：2023年第8卷第4期

页      面：565-577页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071009[理学-细胞生物学] 0836[工学-生物工程] 

基　　金：supported by National Key Research&Development Program of China(2018YFA0900504,2020YFA0907700,and 2018YFA0900300) the National Natural Foundation of China(31401674) the National First-Class Discipline Program of Light Industry Technology and Engineering(LITE2018-22) the Top-notch Academic Programs Project of Jiangsu Higher Education Institutions.This research grant was awarded to author Youran Li. 

主　　题：Transcription factors Binding sites Database-based prediction Experimental identification Cell engineering Biomanufacturing 

摘      要：Transcription factors play an indispensable role in maintaining cellular viability and finely regulating complex internal metabolic networks.These crucial bioactive functions rely on their ability to respond to effectors and concurrently interact with binding sites.Recent advancements have brought innovative insights into the understanding of transcription factors.In this review,we comprehensively summarize the mechanisms by which transcription factors carry out their functions,along with calculation and experimental-based methods employed in their identification.Additionally,we highlight recent achievements in the application of transcription factors in various biotechnological fields,including cell engineering,human health,and biomanufacturing.Finally,the current limitations of research and provide prospects for future investigations are discussed.This review will provide enlightening theoretical guidance for transcription factors engineering.