Detection of periodontal pathogens in the patients with aortic aneurysm

作     者：Ding Fang Lyu Yalin Han Xiao Zhang Hai Liu Dongyu Hei Wei Liu Yinhua 

作者机构：Department of S(omatology Beijing Anzhen Hospital Capital Medical University Beijing 100029 China Department of Restorative Dentistry School of Dentistry University of Washington Seattle Washington USA 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2014年第127卷第23期

页      面：4114-4118页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：This study was supported by grant from National Natural Science Foundation of China (No. 81170282).Acknowledgments: The authors sincerely thank Prof: Du Jie  Prof. Sun Lizhong  and Prof. Zhang Hongjia for their contributions. The authors are also grateful to Dr. Hollie Wash (University of Washington) for her kind contribution to manuscript/English editing 

主　　题：chronic periodontitis aortic aneurysm periodontal pathogens 

摘      要：Background The occurrence and development of aortic aneurysm （AA） are associated with *** researchers have detected the DNA of periodontal pathogens in AA samples in certain ***,it has not been done in Chinese *** objective of this study was to evaluate the prevalence of periodontal pathogens in oral tissue samples and aneurysm samples of AA *** Eighty-nine subjects with AA and 59 subjects without AA were *** clinical parameters were *** saliva and subgingival plaque somples were collected from all ***-six dissected AA samples were *** of eight periodontal pathogens including Porphyromonas gingivalis （Pg）,Actinobacillus actinomycetemcomitans （Aa）,Prevotella intermedia （Pi）,Tannerella forsythensis （Tf）,Treponema denticola （Td）,Campylobacter rectus （Cr）,Fusobacterium nucleatum （Fn）,and Prevotella nigrescens （Pn） was ascertained in all samples by 16S rRNA-based polymerase chain reaction （PCR） *** The periodontal indexes including plaque index （PLI）,probing depth （PD）,bleeding index （BI）,and clinical attachment loss （CAL）,of the six Ramfjord index teeth were significantly higher in the AA group than those in the control group （P 0.01）.Eight periodontal pathogens in subgingival plaque samples were more frequently detected in the AA group than in control *** difference in prevalence between the groups was significant for six （out of eight） periodontal pathogens assayed （Pg,Pi,Fn,Pn,Tf,and Td,P 0.01）.Additionally,all eight periodontal pathogens were more frequently detected in saliva samples of the AA group than in those of the control group,again with six （out of eight） （Pg,Pi,Fn,Cr,Tf,and Td） displaying significant differences in prevalence between the two groups （P 0.01）.Out of 26 aneurysm samples examined,Pg,Pi,Fn,Crand Tfwere detected in 6 （23.1％）,2 （7.7％）,3 （11.5％）,1 （3.8％）,2 （7.7％）,respectively,and Aa,Pn,and Td were not detected in diss