Multifunctional nanoparticle-mediated combining therapy for human diseases
作者机构：School of PharmacyChina Pharmaceutical UniversityNanjing 2111198PR China Xiangya School of Pharmaceutical SciencesCentral South UniversityChangsha 410013PR China Shanghai Skin Disease HospitalTongji University School of MedicineShanghai 200443China
出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)
年 卷 期：2024年第9卷第2期
页 面：343-375页
核心收录：
学科分类：0710[理学-生物学] 07[理学] 070205[理学-凝聚态物理] 0702[理学-物理学]
基 金：supported by the National Natural Science Foundation of China(Nos.81872823,82073782 and 82241002) the Shanghai Science and Technology Committee(No.19430741500) the Key Laboratory of Modern Chinese Medicine Preparation of Ministry of Education of Jiangxi University of Traditional Chinese Medicine(days-202103).
主 题：drugs diseases prevention
摘 要：Combining existing drug therapy is essential in developing new therapeutic agents in disease prevention and treatment.In preclinical investigations,combined effect of certain known drugs has been well established in treating extensive human diseases.Attributed to synergistic effects by targeting various disease pathways and advantages,such as reduced administration dose,decreased toxicity,and alleviated drug resistance,combinatorial treatment is now being pursued by delivering therapeutic agents to combat major clinical illnesses,such as cancer,atherosclerosis,pulmonary hypertension,myocarditis,rheumatoid arthritis,inflammatory bowel disease,metabolic disorders and neurodegenerative diseases.Combinatorial therapy involves combining or co-delivering two or more drugs for treating a specific disease.Nanoparticle(NP)-mediated drug delivery systems,i.e.,liposomal NPs,polymeric NPs and nanocrystals,are of great interest in combinatorial therapy for a wide range of disorders due to targeted drug delivery,extended drug release,and higher drug stability to avoid rapid clearance at infected areas.This review summarizes various targets of diseases,preclinical or clinically approved drug combinations and the development of multifunctional NPs for combining therapy and emphasizes combinatorial therapeutic strategies based on drug delivery for treating severe clinical diseases.Ultimately,we discuss the challenging of developing NP-codelivery and translation and provide potential approaches to address the limitations.This review offers a comprehensive overview for recent cutting-edge and challenging in developing NP-mediated combination therapy for human diseases.
维普期刊数据库