Long-term oncologic outcomes of laparoscopic versus open partial nephrectomy

作     者：ZHENG Jun-hua ZHANG Xiao-long GENG Jiang GUO Chang-cheng ZHANG Xiao-peng CHE Jian-ping YAN Yang PENG Bo WANG Guang-chun XIA sheng-qiang WU Yan 

作者机构：Tongji Univ Dept Urol Shanghai Peoples Hosp 10 Shanghai 200072 Peoples R China Nanjing Med Univ Dept Urol Clin Med Coll 1 Nanjing 210002 Jiangsu Peoples R China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2013年第126卷第15期

页      面：2938-2942页

核心收录：

学科分类：12[管理学] 1201[管理学-管理科学与工程(可授管理学、工学学位)] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：laparoscopic partial nephrectomy meta-analysis outcome open partial nephrectomy renal tumor 

摘      要：Background Most of the literatures on laparoscopic partial nephrectomy （LPN） versus open partial nephrectomy （OPN） focus on technical details and early or mid-term oncologic outcomes, reflecting that the approach is safe and provides mid- term benefits compared with traditional open surgery. However, the difference of long-term oncologic outcome between LPN and OPN remains unclear. The aim of this meta-analysis was to evaluate the long-term oncologic outcome of LPN in the treatment of localized renal tumors compared with that of OPN. Methods A systematic search of electronic databases including Medline, Embase, and Cochrane library was conducted. Comparative studies reporting on long-term oncologic outcome of LPN versus OPN were regarded eligible. The odds ratio （OR） and its corresponding 95% confidence intervals （CO were calculated for the oncologic outcomes. The methodologic quality of the included studies was evaluated using the strict criteria of the Newcastle-Ottawa scale. Results Six comparative studies （1495 participants including 555 LPN and 940 OPN） were included in the present study. There was no significant difference between LPN and OPN in 5-year overall survival （OS） rates （OR=1.83, 95% Cl （0.80, 4.19））, 5-year cancer specific survival （CSS） rates （OR=1.09, 95% CI （0.62, 1.92））, and 5-year recurrence free survival （RFS） rates （OR=0.68, 95% CI （0.37, 1.26））. Conclusion The results of this meta-analysis revealed that there was no significant difference in long-term oncologic outcome between LPN and OPN for treatment of localized renal tumors.