Overexpression of lysine specific demethylase 1 predicts worse prognosis in primary hepatocellular carcinoma patients
Overexpression of lysine specific demethylase 1 predicts worse prognosis in primary hepatocellular carcinoma patients作者机构：Department of General SurgeryXinhua Hospital Affiliated to Shanghai Jiaotong University Department of General SurgeryYixing People's Hospital Department of General SurgeryNorthern Jiangsu People's Hospital
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2012年第18卷第45期
页 面：6651-6656页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Hepatocellular carcinoma Lysine specificdemethylase 1 Tumor progression Prognosis
摘 要：AIM:To investigate the clinicopathological features and prognostic value of lysine specific demethylase 1(LSD1) in hepatocellular carcinoma(HCC).METHODS:We examined LSD1 expression in 60 paired liver cancer tissues and adjacent noncancerous tissues by quantitative real time polymerase chain reaction(qRT-PCR) and Western *** addition,we analyzed LSD1 expression in 198 HCC samples by *** relationship between LSD1 expression,clinicopathological features and patient survival was ***:Immunohistochemistry,Western blotting,and qRT-PCR consistently confirmed LSD1 overexpression in HCC tissues compared to adjacent non-neoplastic tissues(P 0.01).Additionally,immunostaining showed more LSD1-positive cells in the higher tumor stage(T3-4) and tumor grade(G3) than in the lower tumor stage(T1-2,P 0.001) and tumor grade(G1-2,P 0.001),***,HCC patients with high LSD1 expression had significantly lower 5-year overall survival rates(P 0.001) and lower 5-year disease-free survival rates(P 0.001),respectively.A Cox proportional hazards model further demonstrated that LSD1 over-expression was an independent predictor of poor prognosis for both 5-year disease-free survival [hazards ratio(HR) = 1.426,95%CI:0.672-2.146,P 0.001] and 5-year overall survival(HR = 2.456,95%CI:1.234-3.932,P 0.001) in ***:Our data suggest for the first time that the overexpression of LSD1 protein in HCC tissues indicates tumor progression and predicts poor prognosis.
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