Deciphering the placental abnormalities associated with somatic cell nuclear transfer at single-nucleus resolution
作者机构：College of Life SciencesNortheast Agricultural UniversityHarbin 150030China State Key Laboratory of Stem Cell and Reproductive BiologyInstitute of ZoologyChinese Academy of SciencesBeijing 100101China Institute for Stem Cell and Regenerative MedicineChinese Academy of SciencesBeijing 100101China Savaid Medical SchoolUniversity of Chinese Academy of SciencesBeijing 100049China University of Chinese Academy of SciencesBeijing 100049China Beijing Institute for Stem Cell and Regenerative MedicineBeijing 100101China
出 版 物：《Protein & Cell》 (蛋白质与细胞（英文版）)
年 卷 期：2023年第14卷第12期
页 面：924-928页
核心收录：
学科分类：0710[理学-生物学] 1002[医学-临床医学] 100211[医学-妇产科学] 10[医学]
基 金：supported by the National Key Research and Development Program of China(2018YFE0201100 to Lw.,2019YFA0110901 to G.F,2022YFA1104101 to GF,2022YFA1104300 to CL.) the Youth Innovation Promotion Association,CAS(2019084 to GF),informatization Plan of Chinese Academy of Sciences(CAS-Wx20215F-0101 to GF) the National Natural Science Foundation of China(31972895 toLw).
摘 要：Dear Editor,The placenta connecting the fetus to the matermal uterus provides material exchange and an immune-tolerant environment for the embryo in all eutherian mammals(Shao et al.,2022).The representative mouse placenta displays a multilayered structure with distinct characteristics and functions,including the matermal decidua,junctional zone,and labyrinth layer(Marsh and Blelloch,2020).The decidua,which is thought to be derived from the matermal endometrium(and further undergoes decidualization),provides an anchor for fetal trophoblast invasion.The junctional zone predominantly contains spongiotrophoblasts(SpT),glycogen trophoblasts(GlyT),and trophoblast giant cells(TGCs).The labyrinth is the innermost two-layer structure,which mainly consists of syncytiotrophoblast cells(SynTI and SynTII),sinusoidal TGCs(S-TGCs),and fetal endothelial cells(Simmons and Cross,2005).
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