Iron-Catalyzed Amide Bond Formation from Carboxylic Acids and Isocyanates

作     者：Lingjian Zi Jing Zhang Lingjian Zi;Jing Zhang

作者机构：The Institute for Advanced StudiesWuhan UniversityWuhanHubei430072 China 

出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)

年 卷 期：2023年第41卷第23期

页      面：3268-3274页

核心收录：

学科分类：07[理学] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：the National Natural Science Foundation of China(22071185 22271224) Wuhan University startup funding for financial support. 

主　　题：Iroen Carboxylic acids Amides C—N bond formation Rearrangement 

摘      要：We describe an iron-catalyzed amide bond formation from readily available carboxylic acids and isocyanates.This method utilizes an abundant and biocompatible iron catalyst and easily accessible starting materials,generates CO_(2) as the only byproduct,and features broad substrate scopes with good functional group compatibility.Therefore,it provides a cost-effective and practical protocol to access a diverse variety of amides.