Total Synthesis of Syringin and Its Natural Analogues via C—C Bond Activation of Aryl Ketones
作者机构：School of Chinese Materia MedicaNanjing University of Chinese MedicineNanjingJiangsu210023 China CAS Key Laboratory of Receptor ResearchState Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203 China University of Chinese Academy of SciencesBeijing100049 China
出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)
年 卷 期：2023年第41卷第24期
页 面：3587-3592页
核心收录：
学科分类：07[理学] 070303[理学-有机化学] 0703[理学-化学]
基 金：supported by the Shanghai Institute of Materia Medica,the Chinese Academy of Sciences,the National Natural Science Foundation of China(21772211,21920102003) the Institutes for Drug Discovery and Development,Chinese Academy of Sciences(CASIMM0120163006) the Science and Technology Commission of Shanghai Miunicipality(17JC1405000,18431907100) the Program of Shanghai Academic Research Leader(19xD1424600) the National Science&Technology Major Project"Key New Drug Creation and Manufacturing Program",China(2018ZX09711002-006).
主 题：Syringin Total synthesis Cross-coupling C—C activation Syringin analogues
摘 要：Syringin is found in the root of Acanthopanax senticosus(Rupr.Maxim.)Harms and belongs to the lignin chemical compound with many biological activities.In this study,we employed commercially available starting materials and accomplished the total synthesis of syringin in 5 steps with an overall yield of 58%.Palladium-catalyzed C(O)–C bond activation and subsequent cross coupling reaction is the key to construct syringin and its natural analogues.
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