Oxygen administration in the care of neonates： a double-edged sword

作     者：Phyllis A. Dennery 

作者机构：University of Pennsylvania School of Medicine Children's Hospital of Philadelphia Philadelphia PA 19072 USA 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2010年第123卷第20期

页      面：2938-2942页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

主　　题：supplemental oxygen prematurity retinopathy of prematurity bronchopulmonary dysplasia 

摘      要：Objective To evaluate the use of oxygen in neonates in the past, present and future Data sources The data are mainly from Pubmed with relevant published articles from the 1940s to the present with some information gathered from web *** selection Studies evaluating the use of oxygen in premature and term infants through history with original milestone articles *** There are still many unknowns about the proper use of oxygen in preterm and term infants but many studies suggest that both liberal use （resulting in a blood oxygen saturation of greater than 94%） as well as restrictive use （resulting in a blood oxygen saturation of less than 80%-85%） are detrimental and have long term consequences on the *** Definitive studies evaluating the appropriate concentration and duration of supplemental oxygen are ongoing and will help in the management of term and preterm infants requiring oxygen.