Cobalt-Catalyzed Difunctionalization of Styrenes via Ligand Relay Catalysis

作     者：Bingcheng Wang Yufeng Sun Zhan Lu Bingcheng Wang;Yufeng Sun;Zhan Lu

作者机构：Department of ChemistryZhejiang UniversityHangzhouZhejiang310058 China College of ChemistryZhengzhou UniversityZhengzhouHenan450001 China 

出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)

年 卷 期：2023年第41卷第24期

页      面：3633-3638页

核心收录：

学科分类：07[理学] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：Financial supports were provided by the National Key R&D Program of China(2021YFA1500200 and 2021YFF0701600) the NSFC(22271249) the Fundamental Research Funds for the Central Universities(226-2022-00224 and 226-2023-00115). 

主　　题：Ligand relay catalysis Difunctionalization Styrene Alkoxysilane Hydroamination Diazo compounds 

摘      要：Here,we report a cobalt-catalyzed sequential dehydrogenative Heck silylation/hydroamination of styrenes with hydrosilane and diazo compound to access 1-amino-2-silyl compounds with excellent regioselectivity.This difunctionalization reaction could undergo smoothly using 1 mol%catalyst loading with good functional group tolerance.Not only di-and tri-substituted hydrosilanes,but also alkoxysilane is suitable,which does explore the scope of the family of 1-amino-2-silyl compounds.The ligand relay phenomenon between neutral tridentate NNN ligand and anionic NNN ligand is observed for the first time via absorption spectral analysis in this one-pot,two-step transformations.The primary mechanism has been proposed based on the control experiments.