Organochlorides Mediate Oxidation Reactions Induced by Low Dose Ionizing Radiation

作     者：Juncheng Liu Tobias G.Brevé Bing Xu Peter-Leon Hagedoorn Antonia G.Denkova Rienk Eelkema 

作者机构：Department of Radiation Science and TechnologyDelft University of Technology2629 JB Delft Department of Chemical EngineeringDelft University of Technology2629 HZ Delft Department of BiotechnologyDelft University of Technology2629 HZ Delft 

出 版 物：《CCS Chemistry》 (中国化学会会刊（英文）)

年 卷 期：2024年第6卷第7期

页      面：1712-1720页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：funding from the Chinese Scholarship Council (J.L.)and the European Research Council (R.E. ERC Consolidator Grant 726381) 

主　　题：drug delivery micelles radiation chemistry reactive oxygen species ionizing radiation reaction mechanisms 

摘      要：The controlled release of drugs using local ionizing radiation presents a promising approach for targeted cancer treatment,particularly when applied in concurrent *** these approaches,radiation-generated reactive species often play an important ***,the reactive species that can be used to trigger release have low yield and lack ***,we demonstrate the generation of highly oxidative species when aqueous solutions containing low concentrations of organochlorides(such as chloroform)are irradiated with ionizing radiation at therapeutically relevant *** reactive species were identified as peroxyl radicals,which formed in a reaction cascade between organochlorides and aqueous *** employed stilbene-based probes to investigate the oxidation process,showing double bond oxidation and *** translate this reactivity into a radiation-sensitive material,we synthesized a micelle-forming amphiphilic block copolymer that has stilbene as the linker between two *** exposure to ionizing radiation,the oxidation of stilbene led to the cleavage of the polymer,which induces the dissociation of the block-copolymer micelles and the release of loaded drugs.