Microfluidic separation of particles by synergistic effect of geometry-induced hydrodynamics and magnetic field

作     者：Du Qiao Hongxia Li Weiping Zhu Lili Zhu Danyang Zhao Honglin Li Du Qiao;Hongxia Li;Weiping Zhu;Lili Zhu;Danyang Zhao;Honglin Li

作者机构：Key Laboratory for Precision & Non-traditional Machining Technology of Ministry of EducationDalian University of TechnologyDalian 116023China Shanghai Key Laboratory of New Drug DesignSchool of PharmacyEast China University of Science and TechnologyShanghai 200237China Lingang LabShanghai 200031China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2024年第35卷第2期

页      面：380-385页

核心收录：

学科分类：08[工学] 0817[工学-化学工程与技术] 081701[工学-化学工程] 0703[理学-化学] 

基　　金：supported by the National Natural Science Foundation of China(Nos.11502044,U1906233) the Fundamental Research Funds for the Central Universities(No.DUT22JC08) the Liaoning Province's Xing Liao Talents Program(No.XLYC2002108) the Dalian City Supports Innovation and Entrepreneurship Projects for High-level Talents(No.2021RD16). 

主　　题：Microfluidic Particle separation Synergistic effect Hydrodynamics Magnetic field Numerical calculation 

摘      要：Microfluidic combined with magnetic field have been demonstrated to be the promising solutions for fast and low-damage particles separation.However,the difficulties in the precise layout of magnets and accurate prediction of particle trajectories lead to under and over separation of target particles.A novel particle separation lab-on-chip(LOC)prototype integrated with microstructures and micropolar arrays is designed and characterized.Meanwhile,a numerical model for the separation of magnetic particles by the synergistic effect of geometry-induced hydrodynamics and magnetic field is constructed.The effect of geometry and magnetic field layout on particle deflection is systematically analyzed to implement accurate prediction of particle trajectories.It is found that the separation efficiency of magnetic particles increased from 50.2%to 91.7%and decreased from 88.6%to 85.7%in the range of depth factors from 15µm to 27µm and width factors from 30µm to 60µm,respectively.In particular,the combined effect of the offset distance of permanent magnets and the distance from the main flow channel exhibits a significant difference from the conventional perception.Finally,the developed LOC prototype was generalized for extension to arbitrary systems.This work provides a new insight and robust method for the microfluidic separation of magnetic particles.