宿主蛋白TOB1通过IFN和EGFR通路影响口蹄疫病毒感染

作     者：Gaochuang Peng Tianran Liu Xiaolan Qi Yuzhe Wang Jingjing Ren Jiangling Peng Xuguang Du Siyu Hu Sen Wu Yaofeng Zhao Dan Li Haixue Zheng 

作者机构：State Key Laboratory of Animal Biotech Breeding College of Biological Sciences National Engineering Laboratory for Animal Breeding Frontiers Science Center for Molecular Design Breeding China Agricultural University Beijing China State Key Laboratory for Animal Disease Control and Prevention College of Veterinary Medicine Lanzhou University Lanzhou Veterinary Research Institute Chinese Academy of Agricultural Sciences Lanzhou China 

出 版 物：《中国兽医科学》 (Chinese Veterinary Science)

年 卷 期：2024年第54卷第8期

页      面：1136-1136页

核心收录：

学科分类：090601[农学-基础兽医学] 09[农学] 0906[农学-兽医学] 

基　　金：Chinese Academy of Agricultural Sciences, CAAS, (1610312021013, 1610312021010) Chinese Academy of Agricultural Sciences, CAAS State Key Laboratory of Veterinary Biotechnology, SKLVB, (SKLVEB2021DBCG01) State Key Laboratory of Veterinary Biotechnology, SKLVB National Key Research and Development Program of China, NKRDPC, (2021YFA0805905, 2023YFF1000900, 2021YFD1800300) National Key Research and Development Program of China, NKRDPC National Natural Science Foundation of China, NSFC, (32272839) National Natural Science Foundation of China, NSFC Chinese Academy of Agricultural Science and Technology Innovation Project, (CAAS-ASTIP-2020-LVRI) Chinese Universities Scientific Fund, (2022TC147) Chinese Universities Scientific Fund 

主　　题：口蹄疫病毒 抗病毒免疫 FMDV 分子育种 宿主蛋白 相互作用机制 

摘      要：口蹄疫病情(FMDV)在与宿主相互作用中进化出了一系列逃逸宿主抗病毒免疫的策略,在分子水平深入挖掘FMDV与宿主相互作用机制是高效疫苗研发和抗病分子育种的前提。2024年3月PLoS Pathogens杂志发表了“A genome-wide CRISPR screening uncovers that TOB1acts as a key host factor for FMDV infection via both IFN and EGFR mediated pathways的研究论文,论文的通讯作者为吴森教授、赵要风教授、李丹研究员、郑海学研究员。该研究利用CRISPR/Cas9敲除技术,在全基因组水平筛选了猪源细胞中与FMDV感染相关的重要宿主因子。