Diagnosis and management of malaria in the intensive care unit

作     者：George Akafity Nicholas Kumi Joyce Ashong George Akafity;Nicholas Kumi;Joyce Ashong

作者机构：Department of ResearchMonitoringand EvaluationCape Coast Teaching HospitalCape CoastGhana Intensive Care UnitDepartment of Critical Care and AnesthesiaCape Coast Teaching HospitalCape Coast Department of Paediatrics and Child HealthCape Coast Teaching HospitalCape CoastGhana 

出 版 物：《Journal of Intensive Medicine》 (重症医学（英文）)

年 卷 期：2024年第4卷第1期

页      面：3-15页

核心收录：

学科分类：1002[医学-临床医学] 1011[医学-护理学（可授医学、理学学位）] 10[医学] 

基　　金：The authors received no funding support for this review. 

主　　题：Malaria Intensive care unit Severe malaria Antimicrobial resistance Antimalarials Artemisinin-based combination therapy 

摘      要：Malaria is responsible for approximately three-quarters of a million deaths in humans globally each year.Most of the morbidity and mortality reported are from Sub-Saharan Africa and Asia,where the disease is endemic.In non-endemic areas,malaria is the most common cause of imported infection and is associated with significant mortality despite recent advancements and investments in elimination programs.Severe malaria often requires intensive care unit admission and can be complicated by cerebral malaria,respiratory distress,acute kidney injury,bleeding complications,and co-infection.Intensive care management includes prompt diagnosis and early initiation of effective antimalarial therapy,recognition of complications,and appropriate supportive care.However,the lack of diagnostic capacities due to limited advances in equipment,personnel,and infrastructure presents a challenge to the effective diagnosis and management of malaria.This article reviews the clinical classification,diagnosis,and management of malaria as relevant to critical care clinicians,highlighting the role of diagnostic capacity,treatment options,and supportive care.