Ru(Ⅱ)-Catalyzed Selective C-H Alkynylation of Isoquinolones,Quinazolones and Phthalazinones with Bromoalkynes
作者机构：State Key Laboratory Base of Eco-Chemical EngineeringCollege of Chemical EngineeringQingdao University of Science and TechnologyQingdaoShandong 266042China State Key Laboratory of Applied Organic ChemistryLanzhou UniversityLanzhouGansu 730000China School of Chemistry and Chemical EngineeringHenan Normal UniversityXinxiangHenan 453007China
出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)
年 卷 期：2024年第42卷第15期
页 面：1686-1690页
核心收录：
学科分类：081704[工学-应用化学] 07[理学] 070304[理学-物理化学(含∶化学物理)] 08[工学] 0817[工学-化学工程与技术] 0703[理学-化学]
基 金：supported by the Natural Science Foundation of Shandong Province(ZR2019BB011) the Scientific Research Foundation of Qingdao University of Science&Technology(010029022)
主 题：Ru(Ⅱ) Alkynylation Isoquinolones Bromoalkynes Heterocyclic compounds C-H activation C-C coupling Synthetic methods
摘 要：A new,selective Ru(Ⅱ)-catalyzed alkynylation reaction of isoquinolones,quinazolones and phthalazinones with readily available bromoalkynes has been *** reaction enables the selective construction of a new C(sp^(2))-C(sp)bond through C-H activation and C-Br functionalization,and offers an effective and selective route to synthesizing highly valuable alkynylated isoquinolone,quinazolone and phthalazinonederivatives with a wide substrate scope and highselectivity.
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