Upper gastrointestinal sensory-motor dysfunction in diabetes mellitus

作     者：Jingbo Zhao Jens Brφndum Frφkjaer Asbjφrn Mohr Drewes Niels Ejskjaer 

作者机构：Center of Excellence in Visceral Biomechanics and Pain Aalborg Hospital Sφndre Skovvej 15 DK-9000 Aalborg Denmark & Center for Sensory-Motor Interactions Department of Health Science Aalborg University Fredrik Bajers Vej 7 D-3 DK-9220 Aalborg Denmark Department of Medicine M (Diabetes & Endocrinology) Aarhus University Hospital Norrebrogade 44 DK 8000 Aarhus C Denmark 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2006年第12卷第18期

页      面：2846-2857页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Supported by the Danish Diabetes Association  the Research Council of North Jutland County  the Toyota Foundation and the SparNord Foundation 

主　　题：Diabetes Esophagus Stomach Intestine Motility Pain Diabetic neuropathy Hyperglycemia Remodeling 

摘      要：Gastrointestinal （GI） sensory-motor abnormalities are common in patients with diabetes mellitus and may involve any part of the GI tract. Abnormalities are frequently sub-clinical, and fortunately only rarely do severe and life-threatening problems occur. The pathogenesis of abnormal upper GI sensory-motor function in diabetes is incompletely understood and is most likely multi-factorial of origin. Diabetic autonomic neuropathy as well as acute suboptimal control of diabetes has been shown to impair GI motor and sensory function. Morphological and biomechanical remodeling of the GI wall develops during the duration of diabetes, and may contribute to motor and sensory dysfunction. In this review sensory and motility disorders of the upper GI tract in diabetes is discussed; and the morphological changes and biomechanical remodeling related to the sensory-motor dysfunction is also addressed.