Fibroblasts:New players in the central nervous system?

作     者：Lihui Duan Xiang Yu Lihui Duan;Xiang Yu

作者机构：State Key Laboratory of Molecular Development BiologyInstitute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Membrane BiologySchool of Life SciencesPeking UniversityBeijing 100871China Peking-Tsinghua Center for Life Sciences and Peking University McGovern InstitutePeking UniversityBeijing 100871China Chinese Institute for Brain ResearchBeijing 102206China 

出 版 物：《Fundamental Research》 (自然科学基础研究（英文版）)

年 卷 期：2024年第4卷第2期

页      面：262-266页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by grants from the National Natural Science Foundation of China(32030049) the Ministry of Science and Technology of China(2021ZD0202500). 

主　　题：Fibroblasts Central nervous system Infection Aging Neurodegenerative diseases Injury 

摘      要：Fibroblasts are typically described as cells that produce extracellular matrix,contribute to the formation of connective tissue,and maintain the structural framework of tissues.Fibroblasts are the first cell type to be transdifferentiated into inducible pluripotent stem cells(iPSCs),demonstrating their versatility and reprogrammability.Currently,there is relatively extensive characterization of the anatomical,molecular,and functional diversity of fibroblasts in different peripheral organs and tissues.With recent advances in single cell RNA sequencing,heterogeneity and diversity of fibroblasts in the central nervous system(CNS)have also begun to emerge.Based on their distinct anatomical locations in the meninges,perivascular space,and choroid plexus,as well as their molecular diversity,important roles for fibroblasts in the CNS have been proposed.Here,we draw inspirations from what is known about fibroblasts in peripheral tissues,in combination with their currently identified CNS locations and molecular characterizations,to propose potential functions of CNS fibroblasts in health and disease.Future studies,using a combination of technologies,will be needed to determine the bona fide in vivo functions of fibroblasts in the CNS.