Palladium-catalyzed S2 glycosylation of phenols

作     者：Yu Zhu P.Andrew Evans 

作者机构：Department of Chemistry Queen's University(Canada) Xiangya School of Pharmaceutical Sciences Central South University 

出 版 物：《Science China Chemistry》 (中国科学:化学(英文版))

年 卷 期：2024年

核心收录：

学科分类：07[理学] 070303[理学-有机化学] 0703[理学-化学] 

摘      要：Glycosides are essential structural motifs present in an array of important medicines, materials, and natural products [1].Nevertheless, the chemo-and stereoselective construction of the glycosidic linkage is a long-standing challenge because relatively minor variations in the glycosyl donor or acceptor’s structure can impact stereoselectivity, thus influencing the product’s functional properties. Historically, glycoside synthesis has relied on activating glycosyl donors to form oxocarbenium ions 2 (or equivalents), which are trapped by the requisite acceptor (Figure 1a).