Therapeutic strategies for peripheral nerve injuries:FK506 and electrostimulation
作者机构：Department of SurgeryDivision of Plastic and Reconstructive SurgeryWashington University School of MedicineSt.LouisMO 63110USA
出 版 物：《Plastic and Aesthetic Research》 (整形与美容研究（英文版）)
年 卷 期：2023年第10卷第1期
页 面：124-136页
学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学]
主 题：Electrical stimulation FK506 peripheral nerve nerve regeneration
摘 要：Efficacious therapeutics for peripheral nerve injuries remain incompletely described in the ***,over the last several decades,delivery of FK506(Tacrolimus)and electrostimulation have demonstrated great promise for supplementing surgical advances in treating peripheral nerve *** review describes the discovery,mechanistic investigations,and clinical translation of these strategies to promote functional ***506 has demonstrated the ability to increase the regeneration rate after nerve injury by a variety of hypothesized mechanisms,yet clinical utility remains limited due to systemic *** administration of FK506 continues to be an active area of inquiry for minimizing side effects while maintaining its neuroregenerative *** of a nerve proximal to the site of surgical nerve repair has demonstrated increased axonal regeneration and accelerated recovery of both motor and sensory *** addition,electrostimulation also appears to improve axon matching during reinnervation from motor to motor and sensory to sensory pathways and is used clinically in our ***,the specific parameters to best incorporate electrostimulation into the operating theater are still *** translational rodent and murine models,surgical techniques and these therapeutic strategies have gradually become more viable as safety profiles and mechanisms are gradually *** review presents the state of the field for these therapeutic avenues and discusses further areas of research.
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