Molecular mechanisms of cellular metabolic homeostasis in stem cells

作     者：Xiaoyu Li Ou Jiang Songlin Wang Xiaoyu Li;Ou Jiang;Songlin Wang

作者机构：Salivary Gland Disease Center and Beijing Key Laboratory of Tooth Regeneration and Function ReconstructionBeijing Laboratory of Oral Health and Beijing Stomatological HospitalCapital Medical UniversityBeijingChina Department of Biochemistry and Molecular BiologySchool of Basic Medical SciencesCapital Medical UniversityBeijingChina Immunology Research Center for Oral and Systemic HealthBeijing Friendship HospitalCapital Medical UniversityBeijingChina Laboratory for Oral and General Health Integration and TranslationBeijing Tiantan HospitalCapital Medical UniversityBeijingChina Research Unit of Tooth Development and RegenerationChinese Academy of Medical SciencesBeijingChina 

出 版 物：《International Journal of Oral Science》 (国际口腔科学杂志（英文版）)

年 卷 期：2023年第15卷第4期

页      面：527-539页

核心收录：

学科分类：1003[医学-口腔医学] 1001[医学-基础医学(可授医学、理学学位)] 100101[医学-人体解剖与组织胚胎学] 10[医学] 

基　　金：the National Natural Science Foundation of China(82030031,L2224038,92149301) Chinese Academy of Medical Sciences Research Unit(2019-12M-5-031) Beijing Municipal Science&Technology Commission(Z181100001718208) Beijing Municipal Education Commission(119207020201) Beijing Municipality Government Grants(Beijing Laboratory of Oral Health-PXM2021_014226_000041,Beijing Scholar Program-PXM2021_014226_000020) Innovation Research Team Project of Beijing Stomatological Hospital,Capital Medical University(CXTD202201) Young Scientist Program of Beijing Stomatological Hospital,Capital Medical University(YSP202308). 

主　　题：homeostasis maintained mechanisms 

摘      要：Many tissues and organ systems have intrinsic regeneration capabilities that are largely driven and maintained by tissue-resident stem cell populations. In recent years, growing evidence has demonstrated that cellular metabolic homeostasis plays a central role in mediating stem cell fate, tissue regeneration, and homeostasis. Thus, a thorough understanding of the mechanisms that regulate metabolic homeostasis in stem cells may contribute to our knowledge on how tissue homeostasis is maintained and provide novel insights for disease management. In this review, we summarize the known relationship between the regulation of metabolic homeostasis and molecular pathways in stem cells. We also discuss potential targets of metabolic homeostasis in disease therapy and describe the current limitations and future directions in the development of these novel therapeutic targets.