帕金森病情感处理过程中丘脑下区域的活化
Activation of the subthalamic region during emotional processing in Parkinson disease作者机构：Sobell Department of Motor Neuroscience and Movement Disorders Institute of Neurology 8-11 Queen Square London WC1N 3BG United Kingdom Dr.
出 版 物：《世界核心医学期刊文摘(神经病学分册)》 (Digest of the World Core Medical Journals.Clinical Neurology)
年 卷 期：2006年第1期
页 面：38-39页
学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学]
摘 要：Objective: To elucidate the involvement of the human subthalamic nucleus (STN) region in the processing or transmission of emotional information. Methods: Local field potentials (LFPs) were recorded from this region in 10 patients with Parkinson disease (PD) undergoing bilateral implantation of the STN for high-frequency stimulation. LFP recordings were made while patients viewed pleasant and unpleasant emotionally arousing and neutral pictures. Results: A significant decrease (event-related desynchronization ERD ) in the local alpha power (8 to 12 Hz) was found for all stimulus categories starting at about 0.5 seconds after stimulus presentation. However, 1 to 2 seconds poststimulus, the ERD was larger in trials of pleasant (mean ERD: 21.6±2.8%; p 0.009) and unpleasant (mean ERD: 15.0±4.2%; p = 0.018) stimuli compared with neutral stimuli (mean ERD: 4.4 ±4.2%). Conclusion: The delayed modulation of alpha activity recorded from the area of the subthalamic nucleus in PD may reflect the processing or transmission of information related to emotional stimuli. “Limbicactivation in the region of the subthalamic nucleus may explain why high-frequency stimulation of the subthalamic nucleus alters affect in some patients with PD.
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