Extracellular vesicles in nanomedicine and regenerative medicine:A review over the last decade

作     者：Saeid Moghassemi Arezoo Dadashzadeh Maria Joãao Sousa Hanne Vlieghe Jie Yang Cecibel María León-Félix Christiani A.Amorim 

作者机构：Pôle de Recherche en Physiopathologie de La ReproductionInstitut de Recherche Expérimentale et CliniqueUniversitéCatholique de LouvainBrusselsBelgium 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2024年第36卷第6期

页      面：126-156页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Erasmus+ Dimension internationale, (DS/VM/CAI45-1011) FNRS-PDR, (T.0004.20) FNRS-PINT-Multi/VA, (R.8002.21) Fonds National de la Recherche Scientifique de Belgique UCLouvain's Fonds spéciaux de recherche, (IREC FSR22) European Cooperation in Science and Technology, COST China Scholarship Council, CSC Horizon 2020 Servier 

主　　题：Extracellular vesicles Exosomes Regenerative medicine Nanomedicine Drug delivery 

摘      要：Small extracellular vesicles(sEVs)are known to be secreted by a vast majority of *** sEVs,specifically exosomes,induce specific cell-to-cell interactions and can activate signaling pathways in recipient cells through fusion or *** nanovesicles possess several desirable properties,making them ideal for regenerative medicine and nanomedicine *** properties include exceptional stability,biocompatibility,wide biodistribution,and minimal ***,the practical utilization of sEVs,particularly in clinical settings and at a large scale,is hindered by the expensive procedures required for their isolation,limited circulation lifetime,and suboptimal targeting *** these challenges,sEVs have demonstrated a remarkable ability to accommodate various cargoes and have found extensive applications in the biomedical *** overcome the limitations of sEVs and broaden their potential applications,researchers should strive to deepen their understanding of current isolation,loading,and characterization ***,acquiring fundamental knowledge about sEVs origins and employing state-of-the-art methodologies in nanomedicine and regenerative medicine can expand the sEVs research *** review provides a comprehensive overview of state-of-the-art exosome-based strategies in diverse nanomedicine domains,encompassing cancer therapy,immunotherapy,and biomarker ***,we emphasize the immense potential of exosomes in regenerative medicine.