Non-Targeted Metabolomics Reveals the Metabolic Alterations in Response to Artificial Selective Breeding in the Fast-Growing Strains of Pacific Oyster

作     者：HU Boyang TIAN Yuan LIU Shikai LI Qi HU Boyang;TIAN Yuan;LIU Shikai;LI Qi

作者机构：Key Laboratory of MaricultureMinistry of EducationOcean University of ChinaQingdao 266003China Laboratory for Marine Fisheries Science and Food Production ProcessesLaoshan LaboratoryQingdao 266237China 

出 版 物：《Journal of Ocean University of China》 (中国海洋大学学报（英文版）)

年 卷 期：2024年第23卷第2期

页      面：518-528页

核心收录：

学科分类：0908[农学-水产] 0707[理学-海洋科学] 09[农学] 

基　　金：supported by grants from the Earmarked Fund for Agriculture Seed Improvement Project of Shandong Province(Nos.2021ZLGX03 and 2022LZGCQY010) the China Agriculture Research System Project(No.CARS-49) 

主　　题：metabolic signature Pacific oyster artificial selection fast-growing trait 

摘      要：Pacific oyster(Crassostrea gigas)is one of the most important mollusks cultured all around the *** breeding programs of Pacific oysters in China is initiated since 2006 and developed the genetically improved strain with fast-growing ***,little is known about the metabolic signatures of the fast-growing *** the present study,the non-targeted metabolomics was performed to analyze the metabolic signatures of adductor muscle tissue in one-year old Pacific oysters from fast-growing strain and the wild population.A total of 7767 and 10174 valid peaks were extracted and quantified in ESI^(+)and ESI^(−)modes,resulting in 399 and 381 annotated metabolites,*** and OPLS-DA revealed that considerable separation among samples from fastgrowing strain and wild population,suggesting the differences in metabolic ***,81 significantly different metabolites(SDMs)were identified in the comparisons between fast-growing strain and wild population,based on the strict *** was found that there were highly correlation and conserved coordination among these *** enrichment analysis indicated that the SDMs were tightly related to pantothenate and CoA biosynthesis,steroid hormone biosynthesis,riboflavin metabolism,and arginine and proline *** them,the CoA biosynthesis and metabolism,affected by pantetheine and pantothenic acid,might be important for the growth of Pacific oysters under artificial selective *** study provides the comprehensive views of metabolic signatures in response to artificially selective breeding,and is helpful to better understand the molecular mechanism of fastgrowing traits in Pacific oysters.