Reprogramming the tumor immune microenvironment via nanomaterial-mediated dynamic therapy
作者机构：Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of EducationCollege of Chemistry and Materials ScienceNorthwest UniversityXi’an 710069China Laboratory of Controllable NanopharmaceuticalsChinese Academy of Sciences(CAS)Center for Excellence in Nanoscience and CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyNational Center for Nanoscience and TechnologyBeijing 100190China Institute of Regenerative and Reconstructive MedicineMed-X InstituteFirst Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710049China
出 版 物：《Nano Research》 (纳米研究（英文版）)
年 卷 期：2023年第16卷第12期
页 面：13100-13112页
核心收录：
学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 0805[工学-材料科学与工程（可授工学、理学学位）] 100103[医学-病原生物学] 0703[理学-化学] 100214[医学-肿瘤学] 10[医学]
基 金：supported by the National Key Research and Development Program of China(No.2022YFC2408000) the National Natural Science Foundation of China(NSFC)(Nos.82072063,32001005,32101136,and 82202306) Key Research and Development Program of Shaanxi Province(No.2023-YBSF-132) Shaanxi Province Youth Science and Technology New Star(No.2022KJXX-09) Natural Science Foundation of Shaanxi Province(No.2020JQ610) Science Foundation of Nanjing Chia Tai Tianqing project(No.TQ202215)
主 题：tumor immunotherapy tumor immune microenvironment nanomaterials reactive oxygen species immune cells
摘 要：Our improved knowledge of tumor immunology laid a solid foundation for the clinical use of tumor immunotherapies such as immune checkpoint blockers,and the efficacy of these drugs increased our confidence that immunomodulation was a viable way of treating *** basis of immunotherapy is to break the immune escape of the tumor and resolve the immune suppressive microenvironment of ***-mediated dynamic therapy(NDT)is an emerging immuno-regulatable type for tumor therapy,whose effects are mediated by increased cellular levels of reactive oxygen species(ROS).ROS is a potent trigger of immunogenic cell death,and this process initiates antitumor *** for use in NDT can be engineered to interact with almost all cell types in the tumor microenvironment to remodel this *** this review,we systematically examined the effects of NDT on four major cell types in the tumor microenvironment,namely tumor cells,lymphocytes,myeloid cells,and tumor stromal *** believe that this review will improve researchers’understanding of the anti-tumor immunity triggered by NDT,and provide ideas and inspiration for how optimally designed NDT schemes can be used to target the cells in the tumor microenvironment.
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