Eco-friendly iron-catalyzed oxidation of unstrained tertiary aromatic alcohols to ketones

作     者：Shanmei Zhu Penghui Hu Mengying Guo Linlin Zhao Linlin Yang Wei-Jin Gu Wei Han Shanmei Zhu;Penghui Hu;Mengying Guo;Linlin Zhao;Linlin Yang;Wei-Jin Gu;Wei Han

作者机构：Jiangsu Collaborative Innovation Center of Biomedical Functional MaterialsJiangsu Key Laboratory of Biofunctional MaterialsKey Laboratory of Applied PhotochemistrySchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2024年第35卷第1期

页      面：250-253页

核心收录：

学科分类：07[理学] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：the Natural Science Foundation of China(No.21776139) the“Qing Lan Project”Young and Middle-aged Academic Leaders of Jiangsu Provincial Colleges and Universities,and the Priority Academic Program Development of Jiangsu Higher Education Institutions. 

主　　题：Iron catalysis C-C bond cleavage Oxidation H_(2)O_(2) Late-stage functionalization 

摘      要：A general,facile and eco-friendly iron catalysis enables oxidation of unstrained tertiary aromatic alcohols to ketones through C-C bond cleavage even with H_(2)O_(2) as the oxidant.Notably,this transformation can tolerate oxidation-labile functional groups.The robustness of this method is further demonstrated on the late-stage oxidation of complex bioactive molecules.