Mutation Characteristics of inhA and katG Genes in Isoniazid-Resistant Mycobacterium Tuberculosis Patients in Xinjiang
作者机构：The Eighth Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830000Xinjiang Uyghur Autonomous RegionChina
出 版 物：《Journal of Clinical and Nursing Research》 (临床护理研究（英文）)
年 卷 期：2024年第8卷第1期
页 面：140-145页
学科分类：1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 1001[医学-基础医学(可授医学、理学学位)] 100103[医学-病原生物学] 10[医学]
主 题：Mycobacterium tuberculosis Drug resistance Isoniazid Gene mutation
摘 要：Objective:To analyze the mutation characteristics of inhA and katG genes in isoniazid-resistant Mycobacterium tuberculosis in ***:The katG and inhA in 148 strains of isoniazid-resistant Mycobacterium tuberculosis were amplified through fluorescence quantitative PCR,and the amplified products were sequenced and ***:The inhA gene mutation rate of 148 strains of isoniazid-resistant mycobacterium tuberculosis was 13.51%(20/148),among which the inhA gene mutation rate among patients of Han,Uygur,and Kazakh ethnicity were 15.87%,13.21%,and 17.65%,*** was no significant difference in the inhA mutation rate among nationalities(c^(2)=2.897,P0.05).The mutation rate of the katG gene was 84.46%(125/148),among which the mutation rates of patients of Han,Uyghur,and Kazak ethnicities were 82.54%,84.91%,and 76.47%,*** Hui and other ethnic groups were all affected by the katG gene *** was no significant difference in the mutation rate of the katG gene among different ethnicities(c^(2)=3.772,P0.05).The mutation rates of the inhA gene in southern Xinjiang,northern Xinjiang,and other provinces were 18.60%,9.28%,and 37.50%,*** mutation rates of the inhA gene in different regions were statistically different(c^(2)=6.381,P0.05)and between southern Xinjiang and other provinces(c^(2)=1.424,P0.05).However,the mutation rate of the inhA gene in patients from other provinces was higher than that in northern Xinjiang(c^(2)=5.539,P0.05).Conclusion:katG gene mutation was predominant in isoniazid-resistant tuberculosis patients in X
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