Luteolin suppresses oral carcinoma 3(OC3) cell growth and migration via modulating polo-like kinase 1(PLK1) expression and cellular energy metabolism

作     者：Pengfei GAO Wentao ZHANG Yujie LIN Ruijie LU Zijian LOU Gang LU Ruolang PAN Yunfang CHEN Pengfei GAO;Wentao ZHANG;Yujie LIN;Ruijie LU;Zijian LOU;Gang LU;Ruolang PAN;Yunfang CHEN

作者机构：Center for Plastic&Reconstructive SurgeryDepartment of StomatologyZhejiang Provincial People's Hospital(Affiliated People's Hospital)Hangzhou Medical CollegeHangzhou 310014China School of StomatologyBengbu Medical CollegeBengbu 233030China The Second Clinical Medical CollegeWenzhou Medical UniversityWenzhou 325035China Key Laboratory of Cell-Based Drug and Applied Technology Development in Zhejiang ProvinceHangzhou 31122China 

出 版 物：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 (浙江大学学报（英文版）B辑（生物医学与生物技术）)

年 卷 期：2023年第24卷第12期

页      面：1151-1158页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100214[医学-肿瘤学] 0836[工学-生物工程] 10[医学] 

基　　金：supported by the Zhejiang Provincial Traditional Chinese Medicine Science and Technology Project(Nos.2019ZB015 and 2019ZA014) China. 

主　　题：PLK1 metabolism drugs 

摘      要：Oral squamous cell carcinoma(OSCC)is a prevalent malignant tumor affecting the head and neck region(Leemans et al.,2018).It is often diagnosed at a later stage,leading to a poor prognosis(Muzaffar et al.,2021;Li et al.,2023).Despite advances in OSCC treatment,the overall 5-year survival rate of OSCC patients remains alarmingly low,falling below 50%(Jehn et al.,2019;Johnson et al.,2020).According to statistics,only 50%of patients with oral cancer can be treated with surgery.Once discovered,it is more frequently at an advanced stage.In addition,owing to the aggressively invasive and metastatic characteristics of OSCC,most patients die within one year of diagnosis.Hence,the pursuit of novel therapeutic drugs and treatments to improve the response of oral cancer to medication,along with a deeper understanding of their effects.