Hypoxia-induced signaling in the cardiovascular system: pathogenesis and therapeutic targets
作者机构：Department of CardiologyAffiliated Hospital of Zunyi Medical UniversityZunyi 563000China Department of CardiologyZhongshan HospitalFudan UniversityShanghai Institute of Cardiovascular DiseasesShanghai 200032China Key Laboratory of Viral Heart DiseasesNational Health CommissionShanghai 200032China Key Laboratory of Viral Heart DiseasesChinese Academy of Medical SciencesShanghai 200032China National Clinical Research Center for Interventional MedicineShanghai 200032China Shanghai Clinical Research Center for Interventional MedicineShanghai 200032China Institutes of Biomedical SciencesFudan UniversityShanghai 200032China
出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)
年 卷 期：2023年第8卷第12期
页 面：5727-5768页
核心收录：
学科分类：0710[理学-生物学] 1001[医学-基础医学(可授医学、理学学位)] 100104[医学-病理学与病理生理学] 10[医学]
基 金：Excellent Young Talent Cultivation Project of Zunyi City, (2022) 366) Shanghai Clinical Research Center for Interventional Medicine, China, (19MC1910300) Shanghai Super Postdoctoral Incentive Program, China, (2022738) National Natural Science Foundation of China, NSFC, (82200290, 82370261, T2288101) National Natural Science Foundation of China, NSFC China Postdoctoral Science Foundation, (2022M710776) China Postdoctoral Science Foundation Guizhou Provincial Science and Technology Department, (2022) Guizhou Provincial Science and Technology Department Chinese Academy of Medical Sciences, CAMS, (2019-I2M-5-060) Chinese Academy of Medical Sciences, CAMS National Postdoctoral Program for Innovative Talents, (BX20220094) National Postdoctoral Program for Innovative Talents
主 题：cardiovascular therapeutic organs
摘 要：Hypoxia,characterized by reduced oxygen concentration,is a significant stressor that affects the survival of aerobic species and plays a prominent role in cardiovascular diseases.From the research history and milestone events related to hypoxia in cardiovascular development and diseases,Thehypoxia-inducible factors(HIFs)switchcan be observed from both temporal and spatial perspectives,encompassing the occurrence and progression of hypoxia(gradual decline in oxygen concentration),the acute and chronic manifestations of hypoxia,and the geographical characteristics of hypoxia(natural selection at high altitudes).Furthermore,hypoxia signaling pathways are associated with natural rhythms,such as diurnal and hibernation processes.In addition to innate factors and natural selection,it has been found that epigenetics,as a postnatal factor,profoundly influences the hypoxic response and progression within the cardiovascular system.Within this intricate process,interactions between different tissues and organs within the cardiovascular system and other systems in the context of hypoxia signaling pathways have been established.Thus,it is the time to summarize and to construct a multi-level regulatory framework of hypoxia signaling and mechanisms in cardiovascular diseases for developing more therapeutic targets and make reasonable advancements in clinical research,including FDA-approved drugs and ongoing clinical trials,to guide future clinical practice in the field of hypoxia signaling in cardiovascular diseases.
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