Advancing our understanding of monocyte HLA-DR,S100A9,and the potential for individualized therapies in sepsis

作     者：Guillaume Monneret Guillaume Monneret

作者机构：Hospices Civils de LyonImmunology LaboratoryHôpital E.Herriot69437 LyonFrance Universitéde LyonEA 7426“Pathophysiology of Injury-Induced Immunosuppression”UniversitéClaude Bernard Lyon-169437 LyonFrance 

出 版 物：《Military Medical Research》 (军事医学研究（英文版）)

年 卷 期：2023年第10卷第6期

页      面：881-883页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100401[医学-流行病与卫生统计学] 10[医学] 

主　　题：Sepsis Monocyte HLA-DR S100A9 Immunosuppression 

摘      要：By def inition, sepsis refers to a life threatening organ dysfunction due to a dysregulated host response to an infection[1]. More precisely, sepsis triggers a multifaceted response characterized by a simultaneous manifestation of proinflammatory and anti-inflammatory elements that disrupt mechanisms intended to maintain homeostasis. Initially, an overwhelming hyperinflammatory reaction ensues, resulting in tissue damage and organ dysfunction.