Crossroads:Pathogenic role and therapeutic targets of neutrophil extracellular traps in rheumatoid arthritis
作者机构：Department of RheumatologyThe First Affiliated Hospital of Anhui University of Chinese MedicineHefei230031China First Clinical Medical SchoolAnhui University of Chinese MedicineHefei230031China Institute of RheumatologyAnhui Academy of Chinese MedicineHefei230031China
出 版 物：《BIOCELL》 (生物细胞（英文）)
年 卷 期：2024年第48卷第1期
页 面：9-19页
核心收录：
学科分类：0710[理学-生物学] 1002[医学-临床医学] 10[医学]
基 金：supported by grants from the National Traditional Chinese Medicine Inheritance and Innovation Project Fund(Development and Reform Office366) National Key Discipline of Traditional Chinese Medicine(Traditional Chinese MedicineNo.85) the Ministry of Science and Technology National Key Research and Development Program Chinese Medicine Modernization Research Key Project(2018YFC1705204) National Nature Fund Program(82074373,82274490,82205090) Anhui Provincial Laboratory of Applied Basis and Development of Internal Medicine of Modern Traditional Chinese Medicine(2016080503B041).
主 题：Rheumatoid arthritis Neutrophil extracellular traps Review
摘 要：Rheumatoid arthritis(RA)is a prevalent autoimmune disease whose main features include chronic synovial inflammation,bone destruction,and joint degeneration.Neutrophils are often considered to be the first responders to inflammation and are a key presence in the inflammatory milieu of RA.Neutrophil extracellular traps(NETs),a meshwork of DNA-histone complexes and proteins released by activated neutrophils,are widely involved in the pathophysiology of autoimmune diseases,especially RA,in addition to playing a key role in the neutrophil innate immune response.NETs have been found to be an important source of citrullinated autoantigen antibodies and inflammatory factor release,which can activate RA synovial fibroblasts(FLS)and cause joint damage.This article reviews the role of NETs in the pathophysiology of RA,demonstrating the application of multiple molecules with various therapies,with a view to informing the discovery and development of novel biomarkers and therapeutic targets for RA.
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