Correlations between phytohemagglutinin response and leukocyte profile,and bactericidal capacity in a wild rodent

作     者：Zhiqiang ZHANG Zhijun ZHAO 

作者机构：College of Animal Science and TechnologyAnhui Agricultural UniversityHefeiChina College of Life and Environmental ScienceWenzhou UniversityWenzhouChina 

出 版 物：《Integrative Zoology》 (整合动物学（英文版）)

年 卷 期：2015年第10卷第3期

页      面：302-310页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This study was supported by a Key Project of Natural Science of the Anhui Province Department of Education,China(KJ2011A114) supported by the State Key Laboratory of Integrated Management of Pest Insects and Rodents,Institute of Zoology,The Chinese Academy of Sciences(ChineseIPM1001)to ZZQ 

主　　题：Cricetulus barabensis neutrophils phytohemagglutinin serum bactericidal capacity striped hamster 

摘      要：phytohemagglutinin(PHA)-induced swelling is widely used to investigate cell-mediated and innate immunity across different vertebrate ***,its physiological mechanism is still an open question due to the complexity of the involved immune *** the present study,we measured the synchronous variations of PHA response,the proportion of different subtypes of leukocytes,as well as serum bactericidal capacity in circulation blood at 6,12 and 24 h after PHA versus PBS injection in striped hamster,Cricetulus ***,the results showed that PHA responses reached a peak at 6 h postinjection,then sharply declined at 12 h and 24 h *** bactericidal capacity was higher at 6 h and 12 h than at 24 *** proportion of different subtypes of leukocytes,as well as the ratio of neutrophils to lymphocytes did not display significant changes across different time ***,PHA response was positively correlated with the proportion of neutrophils and serum bactericidal *** proportion of monocytes was negatively correlated with that of eosinophils and *** proportion of basophils was negatively correlated with that of *** results indicate that earlier enhanced PHA response is important for the striped hamster to cope with changing environmental conditions due to its small body mass,and the increased components of innate immunity in circulation blood may contribute to the enhancement of PHA swelling response.