The DNA damage and regulatory strategy in hematopoietic stem cells after irradiation exposure:Progress and challenges

作     者：Yanying Liu Naicheng Chen Fang Chen Hao Zeng Lijing Yang Junping Wang Mengjia Hu Yanying Liu;Naicheng Chen;Fang Chen;Hao Zeng;Lijing Yang;Junping Wang;Mengjia Hu

作者机构：State Key Laboratory of TraumaBurns and Combined InjuryInstitute of Combined InjuryChongqing Engineering Research Center for NanomedicineCollege of Preventive MedicineThird Military Medical University(Army Medical University)Chongqing 400038China 31612 Unit of PLAFujian 350200China Chinese PLA Center for Disease Control and PreventionBeijing 100071China 

出 版 物：《Radiation Medicine and Protection》 (放射医学与防护（英文）)

年 卷 期：2024年第5卷第1期

页      面：16-23页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by National Natural Science Foundation of China(No.81930090,82203974) Natural Science Foundation of Chongqing City,China(No.CSTB2023NSCQ-MSX0284) Postdoctoral Innovative Talent Support Program of China(No.BX20220398) China Postdoctoral Science Foundation(No.2022M723867) Postdoctoral Innovative Talent Support Program of Chongqing,(No.CQBX2021017)China 

主　　题：Ionizing radiation Hematopoietic stem cell DNA double-strand break DNA damage response DNA damage repair 

摘      要：The hematopoietic system is susceptible to ionizing radiation(IR),which can cause acute hematopoietic failure or long-term *** the most primitive cells of the hematopoietic hierarchy,hematopoietic stem cells(HSCs)maintain lifelong hematopoietic homeostasis and promote hematopoietic regeneration during *** studies have shown that nuclear and mitochondrial genomes are the main targets of radiation injury in *** importantly,the damage of DNA may trigger a series of biological responses that largely determine HSC fate following IR *** some essential pathways and factors involved in DNA injury and damage in HSCs have been revealed,a comprehensive understanding of the biological effects of radiation on HSCs still needs to be *** review focuses on recent insights into the molecular mechanisms underlying DNA damage and repair in HSCs after *** summarize corresponding regulatory measures,which may provide a reference for further research in this field.