Neural Integration of Audiovisual Sensory Inputs in Macaque Amygdala and Adjacent Regions

作     者：Liang Shan Liu Yuan Bo Zhang Jian Ma Xiao Xu Fei Gu Yi Jiang Ji Dai 

作者机构：CAS Key Laboratory of Brain Connectome and Manipulationthe Brain Cognition and Brain Disease Institute(BCBDI)Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research InstitutionsShenzhen 518055China University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Brain and Cognitive ScienceCAS Center for Excellence in Brain Science and Intelligence TechnologyInstitute of PsychologyChinese Academy of SciencesBeijing 100101China Chinese Institute for Brain ResearchBeijing 102206China Shenzhen Technological Research Center for Primate Translational MedicineShenzhen 518055China Key Laboratory of Brain ScienceZunyi Medical UniversityZunyi563000China 

出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)

年 卷 期：2023年第39卷第12期

页      面：1749-1761页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 1001[医学-基础医学(可授医学、理学学位)] 071006[理学-神经生物学] 

基　　金：supported by the National Natural Science Foundation of China(U20A2017 and 31830037) Guangdong Basic and Applied Basic Research Foundation(2020A1515010785,2020A1515111118,and 2022A1515010134) the Youth Innovation Promotion Association of the Chinese Academy of Sciences(2017120) the Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions(NYKFKT2019009) Shenzhen Technological Research Center for Primate Translational Medicine(F-2021-Z99-504979) the Strategic Research Program of the Chinese Academy of Sciences(XDBS01030100 and XDB32010300) Scientific and Technological Innovation 2030(2021ZD0204300) the Fundamental Research Funds for the Central Universities. 

主　　题：Macaque Amygdala-Multisensory Audiovisual integration Neural activity Multichannel recording 

摘      要：Integrating multisensory inputs to generate accurate perception and guide behavior is among the most critical functions of the brain.Subcortical regions such as the amygdala are involved in sensory processing including vision and audition,yet their roles in multisensory integration remain unclear.In this study,we systematically investigated the function of neurons in the amygdala and adjacent regions in integrating audiovisual sensory inputs using a semi-chronic multi-electrode array and multiple combinations of audiovisual stimuli.From a sample of 332 neurons,we showed the diverse response patterns to audiovisual stimuli and the neural characteristics of bimodal over unimodal modulation,which could be classified into four types with differentiated regional origins.Using the hierarchical clustering method,neurons were further clustered into five groups and associated with different integrating functions and sub-regions.Finally,regions distinguishing congruent and incongruent bimodal sensory inputs were identified.Overall,visual processing dominates audiovisual integration in the amygdala and adjacent regions.Our findings shed new light on the neural mechanisms of multisensory integration in the primate brain.