Exploiting the unique interaction characteristics of fast neutrons for improved cancer therapy:A radiobiological perspective

作     者：Festo Kiragga Konstantin Brazovskiy Festo Kiragga;Konstantin Brazovskiy

作者机构：Tomsk Polytechnic UniversitySchool of Nuclear Power and Electrical Engineering30Lenina AvenueTomsk 634050Russian Federation 

出 版 物：《Radiation Medicine and Protection》 (放射医学与防护（英文）)

年 卷 期：2024年第5卷第1期

页      面：24-29页

核心收录：

学科分类：07[理学] 070202[理学-粒子物理与原子核物理] 0702[理学-物理学] 

主　　题：Neutrons Radiation therapy Energy Double-strand break(DSB) 

摘      要：Fast neutrons have sufficient energy to liberate recoil protons,alpha particles,and other products when they interact with the nuclei of the target material through scattering and absorption *** interactions with biological tissues occur mainly with hydrogen nuclei and as the protons interact with the hydrogen in tissues,they create dense ionization chains along their tracks thus depositing *** neutron therapy was pioneered by Robert Stone in 1938 a few years after the discovery of the *** main advantage is the limited sensitivity to hypoxia and treatment of slow-growing tumors hence better local *** is where photon therapy has yet to have much *** deposition by fast neutrons in living tissues is higher than in conventional radiotherapy using mega voltage(MV)photon *** higher energy deposition gives fast neutrons a higher relative biological effectiveness(RBE)in dealing with certain *** neutrons also have a higher linear energy transfer(LET)and can reach deep-sited tumors better than photon *** main challenge with Fast neutron therapy has been extreme toxicity in late-reacting ***,fast neutron therapy holds potential for the treatment of certain tumors by leveraging the unique interaction characteristics of fast neutrons with biological *** review therefore intends to bring this uniqueness to light to enhance the understanding of the radiobiological properties of fast neutrons and the advantages associated with its therapy.