Divergent defluorocarboxylation of α-CF_(3) alkenes with formate via photocatalyzed selective mono-or triple C-F bond cleavage

作     者：Xing-Yu Wang Pei Xu Wen-Wen Liu Hao-Qiang Jiang Song-Lei Zhu Dong Guo Xu Zhu 

作者机构：Jiangsu Key Laboratory of New Drug Research and Clinical PharmacySchool of PharmacyXuzhou Medical UniversityXuzhou 22100China 

出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)

年 卷 期：2024年第67卷第1期

页      面：368-373页

核心收录：

学科分类：07[理学] 081705[工学-工业催化] 070304[理学-物理化学(含∶化学物理)] 08[工学] 0817[工学-化学工程与技术] 0703[理学-化学] 

基　　金：supported by the National Natural Science Foundation of China(22001224) the Natural Science Foundation of Jiangsu Province(BK20201014,BK20200106) the Start-up Funding provided by Xuzhou Medical University also supported by the Jiangsu Specially-Appointed Professor Program(Xu Zhu) Jiangsu Province Shuangchuang PhD Program(Pei Xu,JSSCBS20211267)。 

主　　题：C-F bond activation defluorocarboxylation carbon dioxide radical anion visible light 

摘      要：Unprecedented divergent synthesis of gem-difluorovinylacetic acid and glutaric acid derivatives fromα-CF_(3)alkenes with formate as the carbonyl source was disclosed.The reaction can undergo selective mono-or triple C-F bond cleavage by simply switching the photocatalyst and hydrogen atom transfer(HAT)catalyst under visible-light-induced conditions at room temperature.Foramte acts as both the C1 source and the reductant through the generation of CO_(2)^(·-)species,which underwent Giese radical addition to electron-deficient alkenes to trigger the consecutive C-F bond cleavage and carboxylation process.