Diabetes mellitus and prostate cancer risk:A mendelian randomization analysis

作     者：Jian-Xu Yuan Qing Jiang Sheng-Jie Yu 

作者机构：Department of SurgeryThe Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China 

出 版 物：《World Journal of Diabetes》 (世界糖尿病杂志（英文版）（电子版）)

年 卷 期：2023年第14卷第12期

页      面：1839-1848页

核心收录：

学科分类：1002[医学-临床医学] 10[医学] 

主　　题：Prostate cancer Diabetes mellitus Mendelian randomization analysis Risk factors Genome-wide association study 

摘      要：BACKGROUND Some studies have directed towards an association between diabetes mellitus(DM)and prostate cancer(PCa);however,this specific relationship remains inconclusive.In recent years,Mendelian randomization(MR)has become a widely used analytical method for inferring epidemiological causes.AIM To investigated the potential relationship between DM and PCa using MR.METHODS We downloaded relevant data ondiabetesandPCafrom the IEU OpenGWAS project database,performed three different methods to conduct MR,and carried out sensitivity analysis for verification.RESULTS The results indicated that DM was an independent risk factor for PCa.The odds ratio(OR)values obtained using the inverse variance weighted method in this study were as follows:OR=1.018(95%confidence interval:1.004-1.032),P=0.014.CONCLUSION We found that DM could increase the incidence rate of PCa.