The effect of body weight on the induction of mild hypothermia in a rabbit model of asphyxia cardiac arrest
The effect of body weight on the induction of mild hypothermia in a rabbit model of asphyxia cardiac arrest作者机构：Emergency Center of Zhongnan Hospital Wuhan University China
出 版 物：《Journal of Geriatric Cardiology》 (老年心脏病学杂志（英文版）)
年 卷 期：2010年第7卷第3期
页 面：161-165页
核心收录：
学科分类：1002[医学-临床医学] 0905[农学-畜牧学] 09[农学] 0902[农学-园艺学] 090202[农学-蔬菜学]
基 金：the Natural Science Fund of Hubei Provience China(2008CDB212)
主 题：Cardiac arrest cardiopulmonary resuscitation mild hypothermia body weight
摘 要：Objective To investigate the effect of body weight on the induction of mild hypothermia in a rabbit model of asphyxia cardiac arrest. Methods Twenty-four rabbits were randomized into two groups： the ice bag group and the intravenous 4℃ saline group. Cardiac arrest was induced and after 3 minutes of cardiac arrest, cardiopulmonary resuscitation was begun. Simultaneously, mild hypothermia was induced by putting an ice bag over the abdomen or infusion of 4℃ saline via an ear vein. A 2℃ decrease of rectal temperature was considered as the completion of hypothermia induction. Induction times were recorded, compared, and analyzed with respect to body weight. Results All rabbits had restoration of spontaneous circulation （ROSC） and ROSC lasted during the experiment. Induction time in the ice bag group was significantly shorter than that in the intravenous 4℃ saline group （22.8 ± 4.7 min VS 42.5 ± 4.0 min, P〈 0.001）. Induction time significantly correlated with body weight in the ice bag group （Pearson Correlation： r = 0.725, P = 0.029）, but not in the intravenous 4℃ saline group （Pearson Correlation： P = 0.418）. Conclusions In a rabbit model, induction of mild hypothermia with an ice bag is faster than with intravenous 4~C saline; induction time positively correlates with body weight when an ice bag is used, but not when intravenous 4℃ saline used. The effect of body weight should be considered when choosing an appropriate method to achieve early induction of mild hypothermia
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